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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sack, Brian | SP | Bellefonte Acorns | 23 | 10/16/2018 | Placentia | USA | Right | Right | 6' 6" | 200 lbs | - |
| Saenz, Gilberto | SP | Baltimore Golden Hawks | 25 | 11/25/2016 | Oaxaca | MEX | Right | Right | 5' 10" | 175 lbs | - |
| Salazar, Franklin | 1B | Chihuahua Cartels | 33 | 08/07/2008 | Tampico | MEX | Left | Right | 6' 6" | 205 lbs | - |
| Salinas, Javier | SP | Free Agent | 37 | 10/22/2004 | Zacatecoluca | SLV | Right | Right | 6' 3" | 205 lbs | - |
| Salomon, Jesus | SP | London Jaspers | 24 | 12/02/2017 | Pinar del Rio | CUB | Left | Left | 6' 1" | 200 lbs | $760,000 |
| Sanchez, Jose | SS | Long Island River Otters | 27 | 11/18/2014 | Independence | USA | Right | Right | 6' 0" | 190 lbs | - |
| Sanchez, Patrick | RP | Long Beach Blue Devils | 24 | 06/04/2018 | Newport News | USA | Right | Left | 5' 8" | 175 lbs | - |
| Sanchez, Roberto | SP | Tijuana Dust Dogs | 22 | 05/09/2020 | San Juan del Río | MEX | Right | Right | 6' 3" | 180 lbs | - |
| Santander, Jorge | CF | Omaha Buffaloes | 35 | 01/05/2007 | Santo Domingo | DOM | Right | Right | 6' 4" | 200 lbs | - |
| Santiago, Nick | SP | London Jaspers | 21 | 06/04/2021 | Philadelphia | USA | Right | Right | 6' 0" | 180 lbs | - |
| Santiago, Sandy | RP | Weldon Tsunami | 30 | 06/18/2011 | Motozintla | MEX | Right | Right | 6' 0" | 205 lbs | - |
| Santiago, Vicente | SP | Matanzas Mandarinas | 19 | 07/23/2022 | Villahermosa | MEX | Left | Right | 6' 1" | 185 lbs | - |
| Savage, Dan | SP | Mesa Hawkeyes | 32 | 09/27/2009 | Oak Grove | USA | Left | Left | 6' 2" | 200 lbs | - |
| Scharlau, Bob | CL | Weldon Tsunami | 22 | 02/13/2020 | Pontoon Beach | USA | Right | Right | 6' 4" | 180 lbs | - |
| Scheidegger, Nick | 2B | Hampton Township Buzz | 26 | 10/31/2015 | Las Vegas | USA | Right | Right | 5' 9" | 190 lbs | - |
| Schield, Mike | CL | Mariaville Lake Reds | 19 | 11/20/2022 | State College | USA | Right | Right | 6' 2" | 185 lbs | - |
| Schlaf, Josh | CF | Texas Jets | 30 | 04/08/2012 | Commerce | USA | Right | Right | 6' 0" | 200 lbs | - |
| Scobee, Ben | RP | London Jaspers | 26 | 05/01/2016 | Quincy | USA | Right | Right | 6' 2" | 200 lbs | - |
| Scott, Danny | 3B | Medford Havoc | 24 | 06/05/2018 | Santa Ana | USA | Right | Right | 6' 1" | 190 lbs | $760,000 |
| Seals, Phil | SP | Long Beach Blue Devils | 21 | 09/09/2020 | Mission Viejo | USA | Left | Left | 6' 4" | 200 lbs | - |
| Seavert, Dustin | RP | Tijuana Dust Dogs | 19 | 11/18/2022 | Friendly | USA | Switch | Right | 5' 9" | 160 lbs | - |
| Serrano, Alex | SP | Free Agent | 27 | 07/01/2014 | Carlsbad | USA | Right | Right | 6' 3" | 195 lbs | - |
| Shannon, Blake | 1B | Baltimore Golden Hawks | 19 | 09/21/2022 | Manteca | USA | Right | Right | 6' 2" | 200 lbs | - |
| Shinners, Matt | RP | Bellefonte Acorns | 28 | 04/20/2014 | Fultondale | USA | Right | Right | 6' 4" | 205 lbs | - |
| Sierra, Jason | RF | Long Beach Blue Devils | 34 | 08/04/2007 | Tulsa | USA | Left | Left | 6' 3" | 200 lbs | - |
| Silva, Armando | LF | Medford Havoc | 25 | 10/16/2016 | La Presa | USA | Right | Right | 6' 0" | 195 lbs | - |
| Sjostrand, Jim | SP | Bellefonte Acorns | 24 | 10/23/2017 | Tacoma | USA | Right | Right | 6' 5" | 200 lbs | - |
| Skoog, Chris | RP | Mariaville Lake Reds | 22 | 09/10/2019 | Lomita | USA | Right | Right | 6' 2" | 185 lbs | - |
| Slayton, Marcus | SP | Cancun Cubs | 31 | 09/19/2010 | Akron | USA | Left | Right | 6' 1" | 200 lbs | - |
| Smith, Dan | CL | Baltimore Golden Hawks | 25 | 05/21/2017 | Salix-Beauty Line Park | USA | Right | Right | 6' 4" | 200 lbs | $760,000 |
| Smith, Josh | 2B | Omaha Buffaloes | 31 | 04/28/2011 | Valhalla | USA | Right | Right | 5' 10" | 195 lbs | - |
| Snyder, Justin | SP | Long Island River Otters | 32 | 08/18/2009 | Forsyth | USA | Right | Right | 6' 4" | 210 lbs | - |
| Solano, Andres | SP | Weldon Tsunami | 20 | 08/16/2021 | Toluca | MEX | Left | Left | 6' 2" | 185 lbs | - |
| Solorzano, Alex | SS | Mariaville Lake Reds | 35 | 06/24/2006 | Tlaquepaque | MEX | Right | Right | 6' 1" | 200 lbs | - |
| Soto, Alex | RP | Cancun Cubs | 31 | 05/09/2011 | Mexico City | MEX | Right | Right | 5' 11" | 175 lbs | - |
| Soto, Antonio | SP | Bellefonte Acorns | 20 | 04/18/2022 | Juarez | MEX | Left | Left | 6' 1" | 180 lbs | - |
| St. Germaine, Jon | RP | Mariaville Lake Reds | 32 | 01/15/2010 | Hodgenville | USA | Right | Right | 6' 1" | 200 lbs | - |
| Stearns, Stephen | SP | Honolulu Makos | 28 | 07/18/2013 | North Whitehall Township | USA | Right | Right | 6' 2" | 200 lbs | - |
| Stephenson, Matthew | 1B | Waco Guardians | 35 | 10/28/2006 | Cambridge City | USA | Left | Left | 6' 4" | 200 lbs | - |
| Stewart, Chris | 1B | Free Agent | 33 | 05/06/2009 | Great Falls | USA | Right | Right | 6' 1" | 190 lbs | - |
| Stokes, Robby | LF | Waco Guardians | 28 | 11/17/2013 | Middletown | USA | Left | Left | 6' 1" | 200 lbs | $2,400,000 |
| Stone, Zachery | C | Medford Havoc | 29 | 05/31/2013 | Safford | USA | Right | Right | 6' 6" | 200 lbs | - |
| Stoneburner, Tommy | SP | Waco Guardians | 32 | 08/20/2009 | Ames | USA | Switch | Left | 6' 0" | 190 lbs | - |
| Strickland, Josh | 1B | Boulder Gold Miners | 31 | 08/20/2010 | Westerville | USA | Right | Right | 6' 1" | 205 lbs | - |
| Sullivan, Myles | SP | Hampton Township Buzz | 35 | 10/28/2006 | Park Layne | USA | Right | Right | 6' 4" | 195 lbs | - |
