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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sabine, Johnny | SP | Raleigh Spurs | 27 | 10/24/2014 | Kitchener | CAN | Right | Right | 6' 5" | 200 lbs | $760,000 |
| Salazar, Danny | CF | Fresno Rattlers | 27 | 05/05/2015 | Zapopan | MEX | Right | Right | 6' 4" | 200 lbs | - |
| Salazar, David | 2B | Free Agent | 30 | 07/20/2011 | Nogales | MEX | Right | Right | 5' 10" | 200 lbs | - |
| Salazar, Jose | RP | North Salem Steelhounds | 24 | 04/18/2018 | David | PAN | Left | Left | 5' 10" | 165 lbs | - |
| Saldana, Juan | C | Smith Village Matadors | 31 | 10/08/2010 | Jamiltepec | MEX | Right | Right | 6' 0" | 195 lbs | - |
| Saldana, Marco | 1B | New Haven Patriots | 23 | 04/20/2019 | Compton | USA | Right | Right | 6' 0" | 200 lbs | - |
| Samu, Bobby | CL | Edmonton Riverhawks | 20 | 06/09/2022 | Prospect Heights | USA | Switch | Right | 6' 4" | 185 lbs | - |
| Sanchez, Carlos | SS | Newark Silverbacks | 22 | 03/29/2020 | Nicolas Romero | MEX | Right | Right | 6' 2" | 180 lbs | - |
| Sands, Andrew | SS | Fresno Rattlers | 22 | 07/03/2019 | Wakefield-Peacedale | USA | Right | Right | 6' 4" | 195 lbs | - |
| Sandt, Cory | RP | Vancouver Orcas | 31 | 04/09/2011 | Mooresville | USA | Right | Right | 6' 4" | 205 lbs | - |
| Santa Cruz, Francisco | RP | Vancouver Orcas | 30 | 01/27/2012 | Sioux City | USA | Switch | Right | 6' 2" | 195 lbs | - |
| Santamaria, Jorge | C | Fresno Rattlers | 19 | 06/26/2022 | Ocosingo | MEX | Right | Right | 5' 11" | 200 lbs | - |
| Santana, Marco | CF | La Romana Limones | 31 | 04/08/2011 | Victoria | MEX | Right | Right | 6' 4" | 200 lbs | - |
| Schmidt, Steve | RP | Ottawa 67's | 21 | 09/09/2020 | Los Angeles | USA | Right | Left | 5' 10" | 165 lbs | $760,000 |
| Schoch, Mike | 2B | Minneapolis Spirit | 22 | 05/05/2020 | Monroeville | USA | Right | Right | 6' 3" | 180 lbs | - |
| Schrader, John | SP | Wildwood Jets | 31 | 05/17/2011 | Dickinson | USA | Right | Right | 6' 5" | 200 lbs | - |
| Schwieters, Travis | 3B | Halifax Rush | 33 | 11/02/2008 | Rosamond | USA | Right | Right | 6' 0" | 200 lbs | - |
| Scott, Jayden | RP | Minneapolis Spirit | 29 | 06/25/2012 | New York | USA | Left | Right | 6' 3" | 200 lbs | - |
| Scott, T.J. | RP | Free Agent | 34 | 11/04/2007 | Templeton | USA | Left | Left | 6' 3" | 200 lbs | - |
| Seaver, Bobby | C | Free Agent | 37 | 05/29/2005 | Madison | USA | Right | Right | 5' 10" | 195 lbs | - |
| Sell, Staffan | CF | Vancouver Orcas | 34 | 12/06/2007 | Sanibel | USA | Left | Left | 6' 4" | 205 lbs | - |
| Sendim, Jermão | SS | Vancouver Orcas | 35 | 12/29/2006 | Maracay | VEN | Right | Right | 6' 5" | 205 lbs | - |
| Serrette, Chris | SP | Edmonton Riverhawks | 19 | 10/16/2022 | McRoberts | USA | Left | Left | 5' 9" | 165 lbs | - |
| Settle, Adam | 1B | Wasilla Warriors | 23 | 02/24/2019 | Walnut Creek | USA | Right | Right | 6' 7" | 275 lbs | - |
| Shearin, Jerry | SP | Winnipeg Swordsmen | 20 | 10/12/2021 | St. Cloud | USA | Left | Left | 6' 4" | 190 lbs | - |
| Sheats, Bobby | RP | Westerville Vikings | 35 | 12/14/2006 | Hialeah | USA | Left | Right | 6' 6" | 205 lbs | - |
| Shimon, Richard | SS | Winnipeg Swordsmen | 31 | 05/13/2011 | Minerva | USA | Right | Right | 6' 0" | 195 lbs | - |
| Shortt, Mike | CF | Anchorage Seawolves | 28 | 11/19/2013 | Beaverton | USA | Right | Right | 6' 2" | 200 lbs | - |
| Simon, Romain | 2B | Smith Village Matadors | 31 | 10/09/2010 | Delmas | HAI | Left | Right | 6' 2" | 200 lbs | - |
| Smagala, Andy | LF | Wasilla Warriors | 30 | 01/19/2012 | Santa Maria | USA | Right | Right | 6' 3" | 200 lbs | - |
| Small, Kevin | 1B | New Haven Patriots | 27 | 12/25/2014 | North Potomac | USA | Right | Right | 6' 4" | 200 lbs | - |
| Smith, Blair | RP | Otter Lake Caribou | 25 | 01/20/2017 | Laval | CAN | Right | Right | 6' 2" | 200 lbs | - |
| Smith, Carlyle | C | Fresno Rattlers | 20 | 07/04/2021 | Bridge City | USA | Switch | Right | 6' 0" | 200 lbs | - |
| Smith, Kyle | CL | Anchorage Seawolves | 21 | 05/24/2021 | Fruit Cove | USA | Right | Left | 6' 2" | 190 lbs | - |
| Smith, Mike | CL | Portland Bruins | 27 | 08/05/2014 | Wadsworth | USA | Right | Right | 6' 3" | 195 lbs | - |
| Snyder, David | CF | Modoc Red Claws | 35 | 06/03/2007 | Four Corners | USA | Right | Right | 6' 4" | 205 lbs | - |
| Solis, Alfonso | RP | Smith Village Matadors | 30 | 03/11/2012 | Dorr Township | USA | Right | Right | 6' 2" | 195 lbs | - |
| Solis, Juan | LF | Free Agent | 29 | 02/07/2013 | Nether Providence Township | USA | Right | Right | 6' 3" | 200 lbs | - |
| Soria, Joe | RP | Free Agent | 31 | 11/21/2010 | Cleveland | USA | Left | Left | 6' 6" | 200 lbs | - |
| Soria, Melvin | 1B | Free Agent | 34 | 06/29/2007 | Havana | CUB | Right | Right | 6' 4" | 200 lbs | - |
| Sowards, Riley | RP | North Salem Steelhounds | 32 | 09/19/2009 | Eunice | USA | Left | Right | 5' 11" | 200 lbs | - |
| Spellman, Kevin | SP | Fargo Gar | 26 | 09/03/2015 | Jackson | USA | Left | Left | 6' 2" | 200 lbs | - |
| Sprague, Brian | RP | Portland Bruins | 21 | 02/10/2021 | Carlsbad | USA | Left | Right | 6' 5" | 195 lbs | - |
| Springer, Joel | 3B | Otter Lake Caribou | 24 | 10/16/2017 | Fort Wayne | USA | Right | Right | 6' 0" | 220 lbs | - |
| St. Hubert, Malachi | RP | Otter Lake Caribou | 26 | 10/05/2015 | Santa Rosa | USA | Left | Left | 6' 8" | 200 lbs | - |
| Staege, Brian | CF | Vancouver Orcas | 24 | 08/16/2017 | New York | USA | Right | Right | 6' 0" | 190 lbs | - |
| Stone, David | 1B | Vancouver Orcas | 23 | 11/10/2018 | East Providence | USA | Right | Right | 6' 1" | 180 lbs | - |
| Stoner, John | C | New Haven Patriots | 26 | 02/18/2016 | Ajax | CAN | Right | Right | 6' 4" | 235 lbs | $760,000 |
| Swift, Trevor | CF | Pachuca Pirates | 30 | 07/07/2011 | Santa Barbara | USA | Left | Left | 6' 5" | 200 lbs | - |
